Microglial phagocytosis of neurons in neurodegeneration, and its regulation
CA Butler, AS Popescu, EJA Kitchener… - Journal of …, 2021 - Wiley Online Library
There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …
Microglia in the retina: roles in development, maturity, and disease
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
Microglia in CNS development: Sha** the brain for the future
Microglial cells are the resident macrophages of the central nervous system (CNS) and are
mainly known for their roles in neuropathologies. However, major recent developments have …
mainly known for their roles in neuropathologies. However, major recent developments have …
Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission
The continuous crosstalk between microglia and neurons is required for microglia
housekee** functions and contributes to brain homeostasis. Through these exchanges …
housekee** functions and contributes to brain homeostasis. Through these exchanges …
Plasticity of microglia
Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …
during embryogenesis. The nervous tissue environment instigates the phenotypic …
Microglia gone rogue: impacts on psychiatric disorders across the lifespan
Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …
central nervous system (CNS) that have been shown to be important for brain development …
Microglia‐dependent remodeling of neuronal circuits
Microglia are tissue‐resident macrophages responsible for the surveillance, neuronal
support, and immune defense of the brain parenchyma. Recently, the role played by …
support, and immune defense of the brain parenchyma. Recently, the role played by …
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
Brain-resident macrophages, microglia, have been proposed to have an active role in
synaptic refinement and maturation, influencing plasticity and circuit-level connectivity. Here …
synaptic refinement and maturation, influencing plasticity and circuit-level connectivity. Here …
Microglia, cytokines, and neural activity: unexpected interactions in brain development and function
A Ferro, YSS Auguste, L Cheadle - Frontiers in immunology, 2021 - frontiersin.org
Intercellular signaling molecules such as cytokines and their receptors enable immune cells
to communicate with one another and their surrounding microenvironments. Emerging …
to communicate with one another and their surrounding microenvironments. Emerging …
Function and dysfunction of microglia during brain development: consequences for synapses and neural circuits
Many diverse factors, ranging from stress to infections, can perturb brain homeostasis and
alter the physiological activity of microglia, the immune cells of the central nervous system …
alter the physiological activity of microglia, the immune cells of the central nervous system …