Platelets are essential for clotting in the blood and maintenance of normal hemostasis.
Under pathologic conditions such as atherosclerosis, vascular injury often results in …

Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of
polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12 …

It is well established that ferroptosis is primarily controlled by glutathione peroxidase 4
(GPX4). Surprisingly, we observed that p53 activation modulates ferroptotic responses …

Hepatic ischemia–reperfusion (IR) injury is a common clinical issue lacking effective therapy
and validated pharmacological targets. Here, using integrative'omics' analysis, we identified …

Venous thromboembolism (VTE) refers to deep vein thrombosis (DVT), whose consequence
may be a pulmonary embolism (PE). Thrombosis is associated with significant morbidity and …

Objective—Adequate platelet reactivity is required for maintaining hemostasis. However,
excessive platelet reactivity can also lead to the formation of occlusive thrombi. Platelet 12 …

Platelets are small, anucleate cells in the blood that play a crucial role in the hemostatic
response but are also implicated in the pathophysiology of cardiovascular disease. It is …

Phospholipids (PLs) are found in all cell types and are required for structural support and
cell activation signalling pathways. In resting cells, PLs are asymmetrically distributed …

Platelets are essential in maintaining hemostasis following inflammation or injury to the
vasculature. Dysregulated platelet activity often results in thrombotic complications leading …

Abstract Human 12-lipoxygenase (12-LOX) is a key enzyme involved in platelet activation,
and the regulation of its activity has been targeted for the treatment of heparin-induced …