Although a large sample size is useful for the elucidation of what is called 'missing
heritability', which is an unexplained part of a total phenotypic variance in a quantitative trait …

Abstract In the Tohoku Medical Megabank project, genome and omics analyses of
participants in two cohort studies were performed. A part of the data is available at the …

Background: There are only limited numbers of reviews on the association of maternal-child
genetic polymorphisms and environmental and lifestyle-related chemical exposure during …

Abstract The Tohoku Medical Megabank biobank (TMM biobank) is the first major population-
based biobank established in Japan. The TMM biobank was established based on two …

Lung function reflects the ability of the respiratory system and is utilized for the assessment
of respiratory diseases. Because type 2 airway inflammation influences lung function …

We performed a metabolome genome-wide association study for the Japanese population
in the prospective cohort study of Tohoku Medical Megabank. By combining whole-genome …

The Tohoku Medical Megabank (TMM) project was established to provide creative
reconstruction of the Tohoku area that suffered from a huge earthquake and ensuing …

Abstract Background Extramammary Paget disease (EMPD) is a rare cutaneous malignant
neoplasm, and the genomic alterations underlying its pathogenesis are unknown. Objective …

Background: The Tohoku Medical Megabank Project (TMM) was established to realize
personalized healthcare and medicine using genomic and omics data. This study evaluated …

To reveal gene-environment interactions underlying common diseases and estimate the risk
for common diseases, the Tohoku Medical Megabank (TMM) project has conducted …