Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are
overactivated. Overactivation of these immune cells exacerbates the disease process and …

Tumors use multiple mechanisms to actively exclude immune cells involved in antitumor
immunity. Strategies to overcome these exclusion signals remain limited due to an inability …

INTRODUCTION Primary liver tumors and liver metastasis currently represent the leading
cause of cancer-related deaths. The liver intimately cross-talks with the gut and performs …

CD4+ T cell-derived interleukin 21 (IL-21) sustains CD8+ T cell responses during chronic
viral infection, but the helper subset that confers this protection remains unclear. Here, we …

Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

The memory T cell pool functions as a dynamic repository of antigen-experienced T
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
signaling molecules and regulate a host of physiological and disease processes. To better …

Recruitment of effector T cells to inflamed peripheral tissues is regulated by chemokines and
their receptors, but the factors regulating recruitment to tumors remain largely undefined …