Phase reduction and phase-based optimal control for biological systems: a tutorial

B Monga, D Wilson, T Matchen, J Moehlis - Biological cybernetics, 2019 - Springer
A powerful technique for the analysis of nonlinear oscillators is the rigorous reduction to
phase models, with a single variable describing the phase of the oscillation with respect to …

Recent advances in the analysis and control of large populations of neural oscillators

D Wilson, J Moehlis - Annual Reviews in Control, 2022 - Elsevier
Many challenging problems that consider the analysis and control of neural brain rhythms
have been motivated by the advent of deep brain stimulation as a therapeutic treatment for a …

Pulsatile desynchronizing delayed feedback for closed-loop deep brain stimulation

OV Popovych, B Lysyansky, M Rosenblum, A Pikovsky… - PloS one, 2017 - journals.plos.org
High-frequency (HF) deep brain stimulation (DBS) is the gold standard for the treatment of
medically refractory movement disorders like Parkinson's disease, essential tremor, and …

Greater accuracy and broadened applicability of phase reduction using isostable coordinates

D Wilson, B Ermentrout - Journal of mathematical biology, 2018 - Springer
The applicability of phase models is generally limited by the constraint that the dynamics of a
perturbed oscillator must stay near its underlying periodic orbit. Consequently, external …

Neurodynamics

S Coombes, KCA Wedgwood - Texts in applied mathematics, 2023 - Springer
This is a book about 'Neurodynamics'. What we mean is that this is a book about how ideas
from dynamical systems theory have been developed and employed in recent years to give …

Augmented phase reduction of (not so) weakly perturbed coupled oscillators

D Wilson, B Ermentrout - SIAM Review, 2019 - SIAM
While phase reduction is a tremendously useful tool for understanding the dynamics of
weakly perturbed limit cycle oscillators, its assumptions break down as perturbations …

Optimal chaotic desynchronization for neural populations

D Wilson, J Moehlis - SIAM Journal on Applied Dynamical …, 2014 - search.proquest.com
A procedure is developed for finding an energy-optimal stimulus which gives a positive
Lyapunov exponent, and hence desynchronization, for a neural population. The procedure …

Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases

OV Popovych, B Lysyansky, PA Tass - Scientific reports, 2017 - nature.com
Computationally it was shown that desynchronizing delayed feedback stimulation methods
are effective closed-loop techniques for the control of synchronization in ensembles of …

Optimal phase control of biological oscillators using augmented phase reduction

B Monga, J Moehlis - Biological cybernetics, 2019 - Springer
We develop a novel optimal control algorithm to change the phase of an oscillator using a
minimum energy input, which also minimizes the oscillator's transversal distance to the …

Suppressing epileptic activity in a neural mass model using a closed-loop proportional-integral controller

J Wang, E Niebur, J Hu, X Li - Scientific reports, 2016 - nature.com
Closed-loop control is a promising deep brain stimulation (DBS) strategy that could be used
to suppress high-amplitude epileptic activity. However, there are currently no analytical …