Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism for numerous
important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases …

Tyrosyl phosphorylation plays a critical role in multiple signaling pathways regulating innate
and acquired immunity. Although tyrosyl phosphorylation is a reversible process, we know …

Predatory bacteria remain molecularly enigmatic, despite their presence in many microbial
communities. Here we report the complete genome of Bdellovibrio bacteriovorus HD100, a …

Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell
function. We examined the role of PEST domain–enriched tyrosine phosphatase (PEP) in …

The protein tyrosine phosphatase, nonreceptor 22 gene (PTPN22) maps to human
chromosome 1p13. 3‐p13. 1 and encodes an important negative regulator of T‐cell …

Background The large yellow croaker (Pseudosciaena crocea) is an economically important
marine fish in China suffering from severe outbreaks of infectious disease caused by marine …

The trace element zinc is a crucial cofactor for many proteins involved in cellular processes
like differentiation, proliferation and apoptosis. Zinc homeostasis is tightly regulated and …

Gold (I) complexes containing N-heterocyclic carbene ligands were synthesized,
characterized, and along with the antiarthritic drug, auranofin, tested as inhibitors of the …

Alternative splicing of pre‐messenger RNA (mRNA) is a fundamental mechanism by which a
gene can give rise to multiple distinct mRNA transcripts, yielding protein isoforms with …

Receptor‐stimulated generation of intracellular reactive oxygen species (ROS) modulates
signal transduction, although the mechanism (s) is unclear. One potential basis is the …