The pathology of small airways disease in COPD: historical aspects and future directions
A Higham, AM Quinn, JED Cançado, D Singh - Respiratory research, 2019 - Springer
Small airways disease (SAD) is a cardinal feature of chronic obstructive pulmonary disease
(COPD) first recognized in the nineteenth century. The diverse histopathological features …
(COPD) first recognized in the nineteenth century. The diverse histopathological features …
COVID-19, COPD, and AECOPD: immunological, epidemiological, and clinical aspects
F Polverino, F Kheradmand - Frontiers in Medicine, 2021 - frontiersin.org
The newly identified severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2)
causes several heterogeneous clinical conditions collectively known as Coronavirus …
causes several heterogeneous clinical conditions collectively known as Coronavirus …
Metformin: experimental and clinical evidence for a potential role in emphysema treatment
Rationale: Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation,
leading to accelerated lung aging, apoptosis, and emphysema, as well as systemic …
leading to accelerated lung aging, apoptosis, and emphysema, as well as systemic …
A jack of all trades–ADAM8 as a signaling hub in inflammation and cancer
L Cook, FG Gharzia, JW Bartsch, D Yildiz - The FEBS Journal, 2024 - Wiley Online Library
As a member of the family of A Disintegrin And Metalloproteinases (ADAM) ADAM8 is
preferentially expressed in lymphatic organs, immune cells, and tumor cells. The substrate …
preferentially expressed in lymphatic organs, immune cells, and tumor cells. The substrate …
Spatial transcriptomics resolve an emphysema-specific lymphoid follicle B cell signature in chronic obstructive pulmonary disease
Rationale: Within chronic obstructive pulmonary disease (COPD), emphysema is
characterized by a significant yet partially understood B cell immune component. Objectives …
characterized by a significant yet partially understood B cell immune component. Objectives …
Does chronic obstructive pulmonary disease originate from different cell types?
The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current
approaches to define distinct disease phenotypes are lacking. In addition to clinical …
approaches to define distinct disease phenotypes are lacking. In addition to clinical …
Unravelling the molecular mechanisms underlying chronic respiratory diseases for the development of novel therapeutics via in vitro experimental models
Chronic respiratory diseases have collectively become a major public health concern and
have now taken form as one of the leading causes of mortality worldwide. Most chronic …
have now taken form as one of the leading causes of mortality worldwide. Most chronic …
Alpha-1 antitrypsin inhibits fractalkine-mediated monocyte-lung endothelial cell interactions
A Mikosz, K Ni, F Gally, KA Pratte… - … of Physiology-Lung …, 2023 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) is characterized by nonresolving
inflammation fueled by breach in the endothelial barrier and leukocyte recruitment into the …
inflammation fueled by breach in the endothelial barrier and leukocyte recruitment into the …
A disintegrin and metalloproteinase-8 protects against erastin-induced neuronal ferroptosis via activating Nrf2/HO-1/FTH1 signaling pathway
Z Qian, Q Zhang, P Li, Y Li, Y Zhang, R Li, T Zhao… - Molecular …, 2024 - Springer
Ferroptosis is a type of iron-dependent programmed cell death caused by the imbalance
between oxidants and antioxidants. A disintegrin and metalloproteinase-8 (ADAM8) is a …
between oxidants and antioxidants. A disintegrin and metalloproteinase-8 (ADAM8) is a …
[HTML][HTML] CC16 augmentation reduces exaggerated COPD-like disease in Cc16-deficient mice
J Rojas-Quintero, ME Laucho-Contreras, X Wang… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract Low Club Cell 16 kDa protein (CC16) plasma levels are linked to accelerated lung
function decline in patients with chronic obstructive pulmonary disease (COPD). Cigarette …
function decline in patients with chronic obstructive pulmonary disease (COPD). Cigarette …