Origins, biology, and diseases of tissue macrophages

N Cox, M Pokrovskii, R Vicario… - Annual review of …, 2021 - annualreviews.org
Tissue-resident macrophages are present in most tissues with developmental, self-renewal,
or functional attributes that do not easily fit into a textbook picture of a plastic and …

Histiocytosis and neoplasms of macrophage-dendritic cell lineages: multimodality imaging with emphasis on PET/CT

KN Huynh, BD Nguyen - Radiographics, 2021 - pubs.rsna.org
Histiocytosis is a rare inflammatory process characterized by pathologic infiltration and
accumulation of cells derived from the monocytic lineage in normal tissue. It encompasses …

Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation

PG Kemps, KM Hebeda, ST Pals… - The Journal of …, 2021 - Wiley Online Library
Histiocytic disorders are a spectrum of rare diseases characterised by the accumulation of
macrophage‐, dendritic cell‐, or monocyte‐differentiated cells in various tissues and organs …

Mimickers of large vessel giant cell arteritis

A Ramon, H Greigert, P Ornetti, B Bonnotte… - Journal of Clinical …, 2022 - mdpi.com
Giant cell arteritis (GCA) is a large-vessel granulomatous vasculitis occurring in patients
over 50-year-old. Diagnosis can be challenging because there is no specific biological test …

Erdheim-Chester disease: a comprehensive review from the ophthalmologic perspective

M Kanakis, P Petrou, G Lourida, I Georgalas - Survey of Ophthalmology, 2022 - Elsevier
Erdheim–Chester disease (ECD) is a rare clonal histiocytic neoplasm with less than 1200
documented cases to date. The disease is life-threatening and difficult to recognize …

Molecular mutations in histiocytosis: a comprehensive survey of genetic alterations

P Pai, A Nirmal, L Mathias, S Jain, MG Shetty… - Molecular …, 2024 - Springer
Histiocytosis represents a group of uncommon disorders characterized by the abnormal
accumulation of specialized immune cells, such as macrophages, dendritic cells, or …

[HTML][HTML] Vemurafenib in the treatment of Erdheim Chester disease: a systematic review

SN Aziz, L Proano, C Cruz, MG Tenemaza, G Monteros… - Cureus, 2022 - ncbi.nlm.nih.gov
Erdheim Chester disease (ECD) is a type of histiocytosis characterized by a variable clinical
presentation. The treatment of ECD is complex and mainly unknown. We aim to conduct a …

[HTML][HTML] Advances in Understanding and Management of Erdheim-Chester Disease

AM Kulkarni, PKR Gayam, JM Aranjani - Life Sciences, 2024 - Elsevier
Abstract Erdheim Chester Disease (ECD) is a rare histiocytic disorder marked by infiltration
of organs with CD68+ histiocytes. ECD stems from mutations of BRAF and MAP2K1 in …

Skeletal involvement in Erdheim-Chester disease: Multimodality imaging features and association with the BRAFV600E mutation

M Nikpanah, FD Firouzabadi, F Farhadi, SM Mirmomen… - Clinical Imaging, 2024 - Elsevier
Objective The aim of this study was to characterize the distribution of skeletal involvement in
Erdheim-Chester disease (ECD) by using radiography, computed tomography (CT), 18 F …

Cyclin D1 expression and molecular genetic findings in periocular histiocytoses and neoplasms of macrophage-dendritic cell lineage

T Milman, M Eiger-Moscovich, RK Henry, CM Ida… - American Journal of …, 2022 - Elsevier
PURPOSE Frequent activating mutations in the mitogen-activated protein kinase (MAPK)
pathway genes have been identified in histiocytoses. MAPK signaling consistently …