Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

Impaired diabetic wounds are serious pathophysiological complications associated with
persistent microbial infections including failure in the closure of wounds, and the cause of a …

Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …

Vascular endothelial growth factor A (VEGF-A), the founding member of the vascular
permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with …

Preeclampsia is an inflammatory disorder in which serum levels of vascular endothelial
growth factor (VEGF) and its soluble receptor-1 (sVEGFR-1, also known as sFlt-1) are …

Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …

Background—Preeclampsia is characterized clinically by hypertension and proteinuria.
Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 …

Endostatin, a fragment of collagen XVIII, is a potent anti-angiogenic protein, but the
molecular mechanism of its action is not yet clear. We examined the effects of endostatin on …

Progranulin (Pgrn) is a pluripotent secreted growth factor that mediates cell cycle
progression and cell motility. It activates the extracellular regulated kinases and …

Nitric oxide (NO) is one of the most pleiotropic signaling molecules at systemic and cellular
levels, participating in vascular tone regulation, cellular respiration, proliferation, apoptosis …