Vagus nerve stimulation for cardiovascular diseases: Is there light at the end of the tunnel?

S Zafeiropoulos, U Ahmed, A Bikou, IT Mughrabi… - Trends in cardiovascular …, 2024 - Elsevier
Autonomic dysfunction and chronic inflammation contribute to the pathogenesis and
progression of several cardiovascular diseases (CVD), such as heart failure with preserved …

Treating heart failure by targeting the vagus nerve

F Gentile, G Orlando, S Montuoro, YF Ferrari Chen… - Heart Failure …, 2024 - Springer
Increased sympathetic and reduced parasympathetic nerve activity is associated with
disease progression and poor outcomes in patients with chronic heart failure. The …

VNS improves VSMC metabolism and arteriogenesis in infarcted hearts through m/n-AChR-Akt-SDF-1α in adult male rats

X Li, JQ Liu, Y Wang, Y Chen, W Hu, Y Lv, Y Wu… - Journal of Molecular …, 2024 - Springer
Vagal nerve stimulation (VNS) provides a novel therapeutic strategy for injured hearts by
activating cholinergic anti-inflammatory pathways. However, little information is available on …

Impact of optimized transcutaneous auricular vagus nerve stimulation on cardiac autonomic profile in healthy subjects and heart failure patients

R Maestri, GD Pinna, E Robbi, C Cogliati… - Physiological …, 2024 - iopscience.iop.org
Objective. To determine the optimal frequency and site of stimulation for transcutaneous
vagus nerve stimulation (tVNS) to induce acute changes in the autonomic profile (heart rate …

Personalized auricular vagus nerve stimulation: beat-to-beat deceleration dominates in systole-gated stimulation during inspiration-a pilot study

J Tischer, JC Szeles, E Kaniusas - Frontiers in Physiology, 2025 - frontiersin.org
Neuromodulation comes into focus as a non-pharmacological therapy with the vagus nerve
as modulation target. The auricular vagus nerve stimulation (aVNS) has emerged to treat …

The utility of heartrate and heartrate variability biofeedback for the improvement of interoception across behavioural, physiological and neural outcome measures: a …

L Wareing, MR Readman, MR Longo, SA Linkenauger… - Brain Sciences, 2024 - mdpi.com
Interoceptive dysfunctions are increasingly implicated in a number of physical and mental
health conditions. Accordingly, there is a pertinent need for therapeutic interventions which …

Effects of auricular vagus nerve stimulation and electrical earlobe stimulation on motor‐evoked potential changes induced by paired associative stimulation

P Haakana, A Nätkynmäki, E Kirveskari… - European Journal of …, 2024 - Wiley Online Library
Paired associative stimulation (PAS) is a combination of transcranial magnetic stimulation
(TMS) and peripheral nerve stimulation (PNS). PAS can induce long‐term potentiation (LTP) …

Feasibility of trancutaneous auricular vagus nerve stimulation in Black and Hispanic/Latino people with peripheral neuropathy

ML Wong, E Widerström-Noga, JL Bolanos… - Frontiers in Pain …, 2025 - frontiersin.org
Introduction Peripheral neuropathy (PN) is the most common neurodegenerative disorder,
and the primary causes are chemotherapy-induced peripheral neuropathy (CIPN) and …

State-and frequency-dependence in autonomic rebalance mediated by intradermal auricular electroacupuncture stimulation

S Yang, YR Wu, Z Zhan, YH Pan… - Frontiers in Neuroscience, 2024 - frontiersin.org
Background Vagus nerve stimulation (VNS) improves diseases such as refractory epilepsy
and treatment-resistant depression, likely by rebalancing the autonomic nervous system …

Computational modelling of cardiac control following myocardial infarction using an in silico patient cohort

MM Gee, AM Lenhoff, JS Schwaber… - The Journal of …, 2024 - Wiley Online Library
Loss of cardiac physiological function following myocardial infarction (MI) is accompanied by
neural adaptations in the baroreflex that are compensatory in the short term, but then …