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The Keap1‐Nrf2 system: a mediator between oxidative stress and aging
C Yu, JH **ao - Oxidative medicine and cellular longevity, 2021 - Wiley Online Library
Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …
The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment
Nrf2 acts as a sensor of oxidative or electrophilic stress and prevents genome instability. The
activation of Nrf2 signaling induces ARE-dependent expression of detoxifying and …
activation of Nrf2 signaling induces ARE-dependent expression of detoxifying and …
Resveratrol and brain mitochondria: a review
Abstract Resveratrol (3, 4', 5-trihydroxystilbene; C 14 H 12 O 3) is a polyphenolic phytoalexin
found in grapes, berries, peanuts, and wines. Resveratrol has been viewed as an …
found in grapes, berries, peanuts, and wines. Resveratrol has been viewed as an …
[HTML][HTML] Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
J Moore, M Yousef, E Tsiani - Nutrients, 2016 - mdpi.com
Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of
cancer cells to evade homeostasis and proliferate uncontrollably while avoiding …
cancer cells to evade homeostasis and proliferate uncontrollably while avoiding …
Neuroprotective effects of carnosic acid: Insight into its mechanisms of action
Carnosic acid is a diterpenoid abundantly present in plants belonging to the genus
Rosmarinus and Salvia of the family Lamiaceae, accounting for their application in …
Rosmarinus and Salvia of the family Lamiaceae, accounting for their application in …
Impact of Advanced Glycation End products (AGEs) and its receptor (RAGE) on cancer metabolic signaling pathways and its progression
Cancer is a complex disease with a 5–10% hereditary base, but nutrition, lifestyle, and the
environment we are exposed to influence 90–95% of cancers. Due to rapid westernization …
environment we are exposed to influence 90–95% of cancers. Due to rapid westernization …
[HTML][HTML] Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials
Alternative treatments for neoplastic diseases with new drugs are necessary because the
clinical effectiveness of chemotherapy is often reduced by collateral effects. Several natural …
clinical effectiveness of chemotherapy is often reduced by collateral effects. Several natural …
[HTML][HTML] Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation
Infertility is a common complication in diabetic men, mainly due to the loss of germ cells by
apoptotic cell death. However, effective and safe approaches to prevent diabetic induction of …
apoptotic cell death. However, effective and safe approaches to prevent diabetic induction of …
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and …
H Li, Z Tang, P Chu, Y Song, Y Yang, B Sun… - Free Radical Biology …, 2018 - Elsevier
Methylglyoxal (MGO), an active metabolite of glucose, is observed in high levels in the
tissues and blood of diabetic patients. Phosphocreatine (PCr), a high-energy phosphate …
tissues and blood of diabetic patients. Phosphocreatine (PCr), a high-energy phosphate …
[HTML][HTML] Attenuation of Nrf2/Keap1/ARE in Alzheimer's disease by plant secondary metabolites: A mechanistic review
Alzheimer's disease (AD) is a progressive neuronal/cognitional dysfunction, leading to
disability and death. Despite advances in revealing the pathophysiological mechanisms …
disability and death. Despite advances in revealing the pathophysiological mechanisms …