The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders
S Zhang, X Peng, S Yang, X Li, M Huang, S Wei… - Cell death & …, 2022 - nature.com
Autophagy is a conserved method of quality control in which cytoplasmic contents are
degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid …
degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid …
Autophagy and disease: unanswered questions
Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …
delivered to the lysosome for degradation and recycling. Autophagy has various …
Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease
Accumulation of neuronal α-synuclein is a prominent feature in Parkinson's disease. More
recently, such abnormal protein aggregation has been reported to spread from cell to cell …
recently, such abnormal protein aggregation has been reported to spread from cell to cell …
Autophagy as a modulator of cell death machinery
The balance between cell death and survival is a critical parameter in the regulation of cells
and the maintenance of homeostasis in vivo. Three major mechanisms for cell death have …
and the maintenance of homeostasis in vivo. Three major mechanisms for cell death have …
The effect of fasting or calorie restriction on autophagy induction: A review of the literature
Autophagy is a lysosomal degradation process and protective housekee** mechanism to
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …
ER stress: Autophagy induction, inhibition and selection
An accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …
The machinery of macroautophagy
Autophagy is a primarily degradative pathway that takes place in all eukaryotic cells. It is
used for recycling cytoplasm to generate macromolecular building blocks and energy under …
used for recycling cytoplasm to generate macromolecular building blocks and energy under …
The autophagosome: origins unknown, biogenesis complex
Healthy cells use autophagy as a general'housekee**'mechanism and to survive stress,
including stress induced by nutrient deprivation. Autophagy is initiated at the isolation …
including stress induced by nutrient deprivation. Autophagy is initiated at the isolation …
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
The lysosome is a degradative organelle, and its fusion with other organelles is strictly
regulated. In contrast to fusion with the late endosome, the mechanisms underlying …
regulated. In contrast to fusion with the late endosome, the mechanisms underlying …
mTOR pathways in cancer and autophagy
TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a
central regulator of cell growth, proliferation and survival in response to nutritional status …
central regulator of cell growth, proliferation and survival in response to nutritional status …