Development and functional diversification of cortical interneurons
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …
collection of cell types that are characterized by their unique spatial and temporal …
Hippocampal GABAergic inhibitory interneurons
KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …
of the total neuronal population; however, their remarkable anatomical and physiological …
Developmental diversification of cortical inhibitory interneurons
C Mayer, C Hafemeister, RC Bandler, R Machold… - Nature, 2018 - nature.com
Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …
investigate how this diversity is generated, here we used single-cell RNA sequencing to …
Interneuron cell types are fit to function
Understanding brain circuits begins with an appreciation of their component parts—the cells.
Although GABAergic interneurons are a minority population within the brain, they are crucial …
Although GABAergic interneurons are a minority population within the brain, they are crucial …
Molecular logic of neocortical projection neuron specification, development and diversity
LC Greig, MB Woodworth, MJ Galazo… - Nature Reviews …, 2013 - nature.com
The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …
neuronal subtypes generated during development under precise molecular regulation. In …
Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
An understanding of the diversity of cortical GABAergic interneurons is critical to understand
the function of the cerebral cortex. Recent data suggest that neurons expressing three …
the function of the cerebral cortex. Recent data suggest that neurons expressing three …
Interneuron types as attractors and controllers
Cortical interneurons display striking differences in shape, physiology, and other attributes,
challenging us to appropriately classify them. We previously suggested that interneuron …
challenging us to appropriately classify them. We previously suggested that interneuron …
A developmental and genetic classification for malformations of cortical development: update 2012
AJ Barkovich, R Guerrini, RI Kuzniecky, GD Jackson… - Brain, 2012 - academic.oup.com
Malformations of cerebral cortical development include a wide range of developmental
disorders that are common causes of neurodevelopmental delay and epilepsy. In addition …
disorders that are common causes of neurodevelopmental delay and epilepsy. In addition …
[HTML][HTML] Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development
CR Nicholas, J Chen, Y Tang, DG Southwell… - Cell stem cell, 2013 - cell.com
Directed differentiation from human pluripotent stem cells (hPSCs) has seen significant
progress in recent years. However, most differentiated populations exhibit immature …
progress in recent years. However, most differentiated populations exhibit immature …