Drugs represent our first, and sometimes last, line of defense for many diseases, yet despite
decades of research we still do not fully understand why a given drug works in one patient …

Survival strategies of human-associated microbes to drug exposure have been mainly
studied in the context of bona fide pathogens exposed to antibiotics. Less well understood …

Autoimmune (or rheumatic) diseases are increasing in prevalence but selecting the best
therapy for each patient proceeds in trial‐and‐error fashion. This strategy can lead to …

The maternal microbiome is emerging as an important factor that influences the neurological
health of mothers and their children. Recent studies highlight how microbial communities in …

Drug safety is a paramount concern in the field of drug development, with researchers
increasingly focusing on the bidirectional regulation of gut microbiota in this context. The gut …

The human gut microbiome, a community of microbes that plays a crucial role in our
wellbeing, is highly adaptable but also vulnerable to drug treatments. This vulnerability can …

Drug-resistant bacteria are outpacing traditional antibiotic discovery efforts. Here, we
computationally screened 444,054 previously reported putative small protein families from …

Transport of small molecules across the bacterial cell envelope is essential to ensure
nutrient uptake and protect bacteria from toxic compounds. Due to its decisive role, transport …

The S1 family of sulfatases is the sole family of enzymes that desulfate carbohydrates,
linking them to inflammatory bowel diseases and various cancers. There is an unmet need …

The human body is home to complex microbial communities that are fundamental to our
physiology. Utilizing mouse models, behavior assays, gene expression analyses, and …