Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead
to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer …

Almost 25 years after the hepatitis C virus (HCV) was identified, and following intense
research and development efforts, a large number of direct-acting antiviral drugs are now …

Objectives Filoviruses such as Ebola virus and Marburg virus cause a severe haemorrhagic
fever syndrome in humans for which there is no specific treatment. Since filoviruses use a …

Although a cure for HCV is on the near horizon, emerging drug cocktails will be expensive,
associated with side-effects and resistance making a global vaccine an urgent priority given …

Cancer is a serious public health problem globally. Many human cancers are induced by
viruses. Understanding of the mechanisms by which oncogenic (tumorigenic) viruses induce …

Conclusions: Taken together, we introduced a multicellular LO model consisting of
hepatocytes, Kupffer-like cells, and HSCs, which recapitulated host-virus …

Hepatitis C virus (HCV) affects approx. 3% of the world's population and accounts for ca 300
000 deaths per year. 80% of individuals with HCV develop chronic symptoms which, when …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the
family of proprotein convertases (PCs), mainly synthetized in hepatic cells. This serine …

Over the last years it has started a real revolution in the treatment of chronic hepatitis C. This
occurred for the availability of direct-acting antiviral agents that allow to reach sustained …

Recent advances in sequencing technologies have greatly enhanced our abilities to identify
novel microbial sequences. Thus, our understanding of the global virome and the virome of …