[HTML][HTML] NF1 deficiency drives metabolic reprogramming in ER+ breast cancer
RRJ House, EA Tovar, LN Redlon, CJ Essenburg… - Molecular …, 2024 - Elsevier
Objective NF1 is a tumor suppressor gene and its protein product, neurofibromin, is a
negative regulator of the RAS pathway. NF1 is one of the top driver mutations in sporadic …
negative regulator of the RAS pathway. NF1 is one of the top driver mutations in sporadic …
Gestational Intermittent Hypoxia Enhances Mammary Stem Cells and Alters Tumor Phenotype in Adult Female Offspring
J Joshi, Y **ong, M Kuhn, AB Radcliff, TL Baker… - Cells, 2024 - mdpi.com
An adverse perinatal environment can increase long-term cancer risk, although the precise
nature of associated perinatal triggers remain unknown. Sleep apnea is a common condition …
nature of associated perinatal triggers remain unknown. Sleep apnea is a common condition …
Nf1 deficiency accelerates mammary development and promotes luminal-basal plasticity
EA Tovar, M Arumugam, CJ Essenburg, PS Dischinger… - bioRxiv, 2022 - biorxiv.org
The tumor suppressor NF1 is a critical driver of sporadic breast cancer and NF-related
breast cancers. We utilized distinct Nf1-deficient immunocompetent rat models to investigate …
breast cancers. We utilized distinct Nf1-deficient immunocompetent rat models to investigate …
Isolation and Culture of Primary Human Mammary Epithelial Cells
L Qian, J Yan, S Chen, MMA Karekad, Y Wu… - JoVE (Journal of …, 2024 - jove.com
The mammary gland is a fundamental structure of the breast and plays an essential role in
reproduction. Human mammary epithelial cells (HMECs), which are the origin cells of breast …
reproduction. Human mammary epithelial cells (HMECs), which are the origin cells of breast …