When normal tissue and tumour samples are compared by microarray analysis, the biggest
differences most often occur in the expression levels of genes that control cell proliferation …

Accurate and complete replication of the genome in every cell division is a prerequisite of
genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely …

We used fluorescence microscopy to measure global and local concentrations of 28
cytoskeletal and signaling proteins fused to yellow fluorescent protein (YFP) in the fission …

Maintenance of a genome requires DNA repair integrated with chromatin remodeling. We
have analyzed six transcriptome data sets and one data set on translational regulation of …

The eukaryotic cell division cycle is a highly regulated process that consists of a complex
series of events and involves thousands of proteins. Researchers have studied the …

Abstract The transcription factors Foxo1, Foxo3 and Foxo4 modulate cell fate'decisions' in
diverse systems. Here we show that Foxo1-dependent gene expression was critical at many …

Summary The Mre11-Rad50-Nbs1 (MRN) complex is a primary sensor of DNA double-
strand breaks (DSBs). Upon recruitment to DSBs, it plays a critical role in catalyzing 5′→ …

We identify the cell cycle–regulated mRNA transcripts genome-wide in the osteosarcoma-
derived U2OS cell line. This results in 2140 transcripts map** to 1871 unique cell cycle …

Mediator is a conserved multi-subunit signal processor through which regulatory
informatiosn conveyed by gene-specific transcription factors is transduced to RNA …

Cell-cycle control of transcription seems to be a universal feature of proliferating cells,
although relatively little is known about its biological significance and conservation between …