The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Many systemic cancer chemotherapies comprise a combination of drugs, yet all clinically
used antibody–drug conjugates (ADCs) contain a single-drug payload. These combination …

Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …

Targeting protein degradation with Proteolysis-Targeting Chimeras (PROTACs) is an area of
great current interest in drug discovery. Nevertheless, although the high effectiveness of …

Paper-based lateral flow immunoassays (LFIAs) are one of the most widely used point-of-
care (PoC) devices; however, their application in early disease diagnostics is often limited …

Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

Bispecific T cell engagers (BiTEs), a subset of bispecific antibodies (bsAbs), can promote a
targeted cancer cell's death by bringing it close to a cytotoxic T cell. Checkpoint inhibitory T …

Simple Summary A proportion of breast tumors bear the oncogenic transmembrane tyrosine
kinase protein HER2. Even though therapies that target HER2 have changed the prognosis …

Ribosomally expressed proteins perform multiple, versatile, and specialized tasks
throughout Nature. In modern times, chemically modified proteins, including improved …

Bioconjugation, the modification of biological macromolecules such as proteins, is an up
and coming area in the field of chemical biology. Antibody-drug conjugates (ADCs) …