Role of EGFR in the Nervous System
Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …
Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain
SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
Acute inflammatory response via neutrophil activation protects against the development of chronic pain
The transition from acute to chronic pain is critically important but not well understood. Here,
we investigated the pathophysiological mechanisms underlying the transition from acute to …
we investigated the pathophysiological mechanisms underlying the transition from acute to …
Transcriptomic sex differences in sensory neuronal populations of mice
J Mecklenburg, Y Zou, A Wangzhou, D Garcia, Z Lai… - Scientific reports, 2020 - nature.com
Many chronic pain conditions show sex differences in their epidemiology. This could be
attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive …
attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive …
Vitamin D and its potential interplay with pain signaling pathways
About 50 million of the US adult population suffer from chronic pain. It is a complex disease
in its own right for which currently available analgesics have been deemed woefully …
in its own right for which currently available analgesics have been deemed woefully …
Human spinal organoid-on-a-chip to model nociceptive circuitry for pain therapeutics discovery
The discovery of new pain therapeutics targeting human nociceptive circuitry is an
emerging, exciting, and rewarding field. However, current models for evaluating prospective …
emerging, exciting, and rewarding field. However, current models for evaluating prospective …
Translational control mechanisms in persistent pain
Persistent pain, which is poorly treated and estimated to afflict one third of the world's
population, is largely mediated by the sensitization of nociceptive neurons. This sensitization …
population, is largely mediated by the sensitization of nociceptive neurons. This sensitization …
Implicative role of epidermal growth factor receptor and its associated signaling partners in the pathogenesis of Alzheimer's disease
Epidermal growth factor receptor (EGFR) plays a pivotal role in early brain development,
although its expression pattern declines in accordance with the maturation of the active …
although its expression pattern declines in accordance with the maturation of the active …
The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain
M Defaye, MC Iftinca, VM Gadotti… - The Journal of …, 2022 - Am Soc Clin Investig
The anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase known for its oncogenic
potential that is involved in the development of the peripheral and central nervous system …
potential that is involved in the development of the peripheral and central nervous system …
Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects
Q Zhang, Y Ren, Y Mo, P Guo, P Liao, Y Luo, J Mu… - Cell Research, 2022 - nature.com
Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDS) produce deleterious side
effects and fail to provide sustained relief in patients with chronic inflammatory pain …
effects and fail to provide sustained relief in patients with chronic inflammatory pain …