Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in
incidence. Although melanoma is a historically treatment-resistant malignancy, in recent …

All cancers originate from a single cell that starts to behave abnormally due to the acquired
somatic mutations in its genome. Until recently, the knowledge of the mutational processes …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal
body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout …

Mutational hotspots indicate selective pressure across a population of tumor samples, but
their prevalence within and across cancer types is incompletely characterized. An approach …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Background Neuropathic pain is a common and severely disabling state that affects millions
of people worldwide. Microglial activation in the spinal cord plays a critical role in the …

Cutaneous squamous cell carcinoma (cSCC) has a high tumour mutational burden (50
mutations per megabase DNA pair). Here, we combine whole-exome analyses from 40 …

Despite recent insights into melanoma genetics, systematic surveys for driver mutations are
challenged by an abundance of passenger mutations caused by carcinogenic UV light …

We characterized the mutational landscape of melanoma, the form of skin cancer with the
highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed …