Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

Static gene expression programs have been extensively characterized in stem cells and
mature human cells. However, the dynamics of RNA isoform changes upon cell-state …

SWI/SNF protein complexes are evolutionarily conserved epigenetic regulators described in
all eukaryotes. In metameric animals, the complexes are involved in all processes occurring …

ATP-dependent chromatin remodelers play a crucial role in modifying chromatin
configuration by utilizing the energy of ATP hydrolysis. They are involved in various …

Significant effort has been spent attempting to unravel the causal relationship between
histone post-translational modifications and fundamental DNA processes, including …

The purpose of this article is to provide a literature review of the epigenetic understanding of
conjunctival melanoma (CM), with a primary focus on current gaps in knowledge and future …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized
by late detection and poor prognosis. Recent research highlights the pivotal role of …

The role of the chromatin remodeler HELicase Lymphoid Specific (HELLS) has been
historically associated with DNA methylation and DNA damage repair. However, recent …

The rapid and accurate diagnosis of rare diseases is paramount in directing clinical
management. In recent years, the integration of multi-omics approaches has emerged as a …