Drug affinity responsive target stability (DARTS) is a novel target discovery approach and is
particularly adept at screening small molecule (SM) targets without requiring any structural …

The global epidemic of diabetes has brought heavy pressure on public health. New effective
anti-diabetes strategies are urgently needed. Trigonelline is the main component of …

Trigonelline is a bioactive pyridine alkaloid that occurs naturally in high concentrations in
coffee (up to 7.2 g/kg) and coffee by-products (up to 62.6 g/kg) such as coffee leaves …

The knowledge of the relationship between the chemical structure of food components with
their mechanisms of action is crucial for the understanding of diet health benefits. This …

Coffee is a popular and widely consumed beverage worldwide, with epidemiological studies
showing reduced risk of cardiovascular disease, cancers and non-alcoholic fatty liver …

Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD+) levels are
hallmarks of skeletal muscle ageing and sarcopenia,–, but it is unclear whether these …

In recent years, exploring natural compounds with functional properties to ameliorate aging-
associated cognitive decline has become a research priority to ensure healthy aging. In the …

Trigonelline is the second most abundant bioactive alkaloid found in coffee. It is classified as
a phytoestrogen with similar structure as of estradiol and exhibits an estrogenic effect. A …

The indiscriminate use of chemical pesticides increasingly harms the health of living beings
and the environment. Thus, biological control carried out by microorganisms has gained …

Ethnopharmacological relevance Alzheimer's disease (AD) is the most prevalent
neurodegenerative disease among old adults. As a traditional Chinese medicine, the herbal …