Quantitative comparison against experiments reveals imperfections in force fields' descriptions of popc–cholesterol interactions
Cholesterol is a central building block in biomembranes, where it induces orientational
order, slows diffusion, renders the membrane stiffer, and drives domain formation. Molecular …
order, slows diffusion, renders the membrane stiffer, and drives domain formation. Molecular …
Advantages of the classical thermodynamic analysis of single—and multi-component Langmuir monolayers from molecules of biomedical importance—theory and …
P Dynarowicz-Latka, A Wnętrzak… - Journal of the …, 2024 - royalsocietypublishing.org
The Langmuir monolayer technique has been successfully used for decades to model
biological membranes and processes occurring at their interfaces. Classically, this method …
biological membranes and processes occurring at their interfaces. Classically, this method …
Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk
Cellular membranes serve as an epicentre combining extracellular and cytosolic
components with membranous effectors, which together support numerous fundamental …
components with membranous effectors, which together support numerous fundamental …
Martini 3 coarse-grained force field for cholesterol
L Borges-Araújo, AC Borges-Araújo… - Journal of Chemical …, 2023 - ACS Publications
Cholesterol plays a crucial role in biomembranes by regulating various properties, such as
fluidity, rigidity, permeability, and organization of lipid bilayers. The latest version of the …
fluidity, rigidity, permeability, and organization of lipid bilayers. The latest version of the …
Cholesterol protects the liquid-ordered phase of raft model membranes from the destructive effect of ionic liquids
XL Hao, B Cao, D Dai, FG Wu… - The Journal of Physical …, 2022 - ACS Publications
Ionic liquids (ILs), although being a class of promising green solvents, have received many
reports on the toxicity to living organisms. In this work, aiming at elucidating the disruptive …
reports on the toxicity to living organisms. In this work, aiming at elucidating the disruptive …
Protein crowding and cholesterol increase cell membrane viscosity in a temperature dependent manner
B Fábián, I Vattulainen… - Journal of Chemical Theory …, 2023 - ACS Publications
Shear viscosity of lipid membranes dictates how fast lipids, proteins, and other membrane
constituents travel along the membrane and rotate around their principal axis, thus …
constituents travel along the membrane and rotate around their principal axis, thus …
Effects of hydrophobic gold nanoparticles on structure and fluidity of SOPC lipid membranes
Gold nanoparticles (AuNPs) are promising candidates in various biomedical applications
such as sensors, imaging, and cancer therapy. Understanding the influence of AuNPs on …
such as sensors, imaging, and cancer therapy. Understanding the influence of AuNPs on …
Phase transition and phase separation in realistic thylakoid lipid membrane of marine algae in all-atom simulations
Thylakoid membranes are specialized membranes predominantly composed of uncommon
galacto-and sulfolipids, having distinct roles in photosynthesis. Large acyl chain variety and …
galacto-and sulfolipids, having distinct roles in photosynthesis. Large acyl chain variety and …
Protein-Mediated Changes in Membrane Fluidity and Ordering: Insights into the Molecular Mechanism and Implications for Cellular Function
Probing protein–membrane interactions is vital for understanding biological functionality for
various applications such as drug development, targeted drug delivery, and creation of …
various applications such as drug development, targeted drug delivery, and creation of …
Understanding the free-energy landscape of phase separation in lipid bilayers using molecular dynamics
AJ Poruthoor, A Sharma, A Grossfield - Biophysical Journal, 2023 - cell.com
Liquid-liquid phase separation inside the cell often results in biological condensates that
can critically affect cell homeostasis. Such phase separation events occur in multiple parts of …
can critically affect cell homeostasis. Such phase separation events occur in multiple parts of …