Ergosterol is an essential component of fungal cell membranes that determines the fluidity,
permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a …

Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …

At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs).
The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma …

The wall gives a Saccharomyces cerevisiae cell its osmotic integrity; defines cell shape
during budding growth, mating, sporulation, and pseudohypha formation; and presents …

Oxysterol-binding protein (OSBP) and its related proteins (ORPs) constitute a large and
evolutionarily conserved family of lipid-binding proteins that target organelle membranes to …

Eukaryotic cells activate the unfolded-protein response (UPR) upon endoplasmic reticulum
(ER) stress, where the stress is assumed to be the accumulation of unfolded proteins in the …

Sphingolipids, which comprise membrane systems together with other lipids, are ubiquitous
in cellular organisms. They show a high degree of diversity across plant species and vary in …

Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization
and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein …

More than 100 mammalian proteins are post-translationally modified by
glycosylphosphatidylinositol (GPI) at their C-termini and are anchored to the cell surface …

We previously reported that glycosylphosphatidylinositol (GPI) biosynthesis is upregulated
when endoplasmic reticulum–associated degradation (ERAD) is defective; however, the …