Deleterious mutations decrease reproductive fitness and are ubiquitous in genomes. Given
that many organisms face ongoing threats of extinction, there is interest in elucidating the …

Deleterious genetic variation is abundant in wild populations, and understanding the
ecological and conservation implications of such variation is an area of active research …

In cases of severe wildlife population decline, a key question is whether recovery efforts will
be impeded by genetic factors, such as inbreeding depression. Decades of excess mortality …

Dominance refers to the effect of a heterozygous genotype relative to that of the two
homozygous genotypes. The degree of dominance of mutations for fitness can have a …

The neutral and nearly neutral theories, introduced more than 50 yr ago, have raised and
still raise passionate discussion regarding the forces governing molecular evolution and …

Inferring the demographic history of populations provides fundamental insights into species
dynamics and is essential for develo** a null model to accurately study selective …

Whether adaptation is limited by the beneficial mutation supply is a long-standing question
of evolutionary genetics, which is more generally related to the determination of the adaptive …

New mutations provide the raw material for evolution and adaptation. The distribution of
fitness effects (DFE) describes the spectrum of effects of new mutations that can occur along …

Small and isolated wildlife populations face numerous threats to extinction, among which is
the deterioration of fitness due to an accumulation of deleterious genetic variation. Genomic …

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