Nanoparticulation of prodrug into medicines for cancer therapy

Y Zhang, H Cui, R Zhang, H Zhang… - Advanced …, 2021 - Wiley Online Library
This article provides a broad spectrum about the nanoprodrug fabrication advances co‐
driven by prodrug and nanotechnology development to potentiate cancer treatment. The …

Merging data curation and machine learning to improve nanomedicines

C Chen, Z Yaari, E Apfelbaum, P Grodzinski… - Advanced drug delivery …, 2022 - Elsevier
Nanomedicine design is often a trial-and-error process, and the optimization of formulations
and in vivo properties requires tremendous benchwork. To expedite the nanomedicine …

DrugMAP: molecular atlas and pharma-information of all drugs

F Li, J Yin, M Lu, M Mou, Z Li, Z Zeng, Y Tan… - Nucleic acids …, 2023 - academic.oup.com
The efficacy and safety of drugs are widely known to be determined by their interactions with
multiple molecules of pharmacological importance, and it is therefore essential to …

Amorphous solid dispersions (asds): The influence of material properties, manufacturing processes and analytical technologies in drug product development

R Iyer, V Petrovska Jovanovska, K Berginc, M Jaklič… - Pharmaceutics, 2021 - mdpi.com
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …

Stimulus-responsive drug delivery nanoplatforms for inflammatory bowel disease therapy

J Long, X Liang, Z Ao, X Tang, C Li, K Yan, X Yu… - Acta Biomaterialia, 2024 - Elsevier
Inflammatory bowel disease (IBD) manifests as inflammation in the colon, rectum, and ileum,
presenting a global health concern with increasing prevalence. Therefore, effective anti …

Towards halal pharmaceutical: Exploring alternatives to animal-based ingredients

Y Herdiana, FF Sofian, S Shamsuddin, T Rusdiana - Heliyon, 2024 - cell.com
Halal is a crucial concept for Muslim consumers regarding consumed products, including
pharmaceutical ingredients, which are essential in modern medicine. To address the issue …

Pervasive transcriptome interactions of protein-targeted drugs

L Fang, WA Velema, Y Lee, L **ao, MG Mohsen… - Nature Chemistry, 2023 - nature.com
The off-target toxicity of drugs targeted to proteins imparts substantial health and economic
costs. Proteome interaction studies can reveal off-target effects with unintended proteins; …

PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells

S Prokop, P Ábrányi-Balogh, B Barti, M Vámosi… - Nature …, 2021 - nature.com
Immunolabeling and autoradiography have traditionally been applied as the methods-of-
choice to visualize and collect molecular information about physiological and pathological …

Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19: a multicentre, randomized …

F Carrouel, M Valette, E Gadea, A Esparcieux… - Clinical Microbiology …, 2021 - Elsevier
Objectives To determine if commercially available mouthwash with β-cyclodextrin and citrox
(bioflavonoids)(CDCM) could decrease the severe acute respiratory syndrome coronavirus …

Pharmaceutical agent cetylpyridinium chloride inhibits immune mast cell function by interfering with calcium mobilization

B Obeng, CM Potts, BE West, JE Burnell… - Food and Chemical …, 2023 - Elsevier
Cetylpyridinium chloride (CPC) is an antimicrobial used in numerous personal care and
janitorial products and food for human consumption at millimolar concentrations. Minimal …