Enantioselective total synthesis of (‒)-lucidumone enabled by tandem prins cyclization/cycloetherification sequence

XZ Liao, R Wang, X Wang, G Li - Nature Communications, 2024 - nature.com
The Ganoderma meroterpenoids are a growing class of natural products with architectural
complexity, and exhibit a wide range of biological activities. Here, we report an …

Mukaiyama aldol reaction: an effective asymmetric approach to access chiral natural products and their derivatives/analogues

A Mushtaq, AF Zahoor - RSC advances, 2023 - pubs.rsc.org
The Mukaiyama aldol reaction is generally a Lewis-acid catalyzed cross-aldol reaction
between an aldehyde or ketone and silyl enol ether. It was first described by Mukaiyama in …

Total Synthesis of Ganoderma Meroterpenoids – Progresses since 2014

Y Kawamoto, H Ito - Asian Journal of Organic Chemistry, 2024 - Wiley Online Library
Meroterpenoids isolated from fungi of the Ganoderma family have received much attention
owing to their unique structures and diverse biological activities. A number of Ganoderma …

Gancochlearols E− I, meroterpenoids from Ganoderma cochlear against COX-2 and triple negative breast cancer cells and the absolute configuration assignment of …

YP Li, XT Jiang, FY Qin, HX Zhang, YX Cheng - Bioorganic chemistry, 2021 - Elsevier
Five new meroterpenoids, gancochlearols E− I (1, 3–6), and one compound ganomycin K
(2) were isolated from the fruiting bodies of G. cochlear. Their structures were assigned by …

Chemical Synthesis and Antifibrotic Properties of (±)-Cochlearol T,(±)-Ganocochlearin A, and (±)-Cochlearol Y

BN Kakde, SW An, YS Jebaraj, S Neelam… - ACS Medicinal …, 2024 - ACS Publications
The cochlearols and ganocochlearins are natural products with unique antifibrotic and
renoprotective activities in models of kidney disease. They represent compelling lead …

Total synthesis of spiro Ganoderma meroterpenoids spiroapplanatumines B, D, F, and H

JH Zhang, WC Luo, WT Chen, YT He… - Organic Chemistry …, 2024 - pubs.rsc.org
The first total synthesis of spiroapplanatumines B (2), D (4), F (6), and H (8) as well as the
possibly undiscovered natural product spiroapplanatumine R (10) has been realized in a …

Lingzhi, an overview

Q Du, Y Cao, C Liu - The lingzhi mushroom genome, 2021 - Springer
Lingzhi mushroom refers to a group of fungal species belonging to the genus Ganoderma.
During the past 10 years, the genetic studies of Lingzhi have made great strides. The …

Pivotal Reactions in the Creation of the Polycyclic Skeleton of Cryptotrione

Z Zhong, MY Lyu, HR Ma, HNC Wong, XS Peng - Synlett, 2021 - thieme-connect.com
Three pivotal reactions, namely, enyne cycloisomerization, polyene cyclization, and quinone
methide formation, are applied to synthesize the complex polycyclic skeleton of cryptotrione …