The acidic tumor microenvironment as a driver of cancer
Acidic metabolic waste products accumulate in the tumor microenvironment because of high
metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and …
metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and …
Nanomedicine for brain cancer
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter-and intratumor heterogeneity
VG LeBlanc, DL Trinh, S Aslanpour, M Hughes… - Cancer Cell, 2022 - cell.com
Glioblastomas (GBMs) are aggressive brain tumors characterized by extensive inter-and
intratumor heterogeneity. Patient-derived models, such as organoids and explants, have …
intratumor heterogeneity. Patient-derived models, such as organoids and explants, have …
Tumor purity as an underlying key factor in glioma
C Zhang, W Cheng, X Ren, Z Wang, X Liu, G Li… - Clinical Cancer …, 2017 - AACR
Purpose: Glioma tissues consist of not only glioma cells but also glioma-associated
nontumor cells, such as stromal cells and immune cells. These nontumor cells dilute the …
nontumor cells, such as stromal cells and immune cells. These nontumor cells dilute the …
Cancer stem cells: understanding tumor hierarchy and heterogeneity
JN Rich - Medicine, 2016 - journals.lww.com
Heterogeneity within and between tumors is a well-known phenomenon that greatly
complicates the diagnosis and treatment of cancer. A large body of research indicates that …
complicates the diagnosis and treatment of cancer. A large body of research indicates that …
Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma
Glioblastoma (GBM) is a lethal and aggressive brain tumor that is resistant to conventional
radiation and cytotoxic chemotherapies. Molecularly targeted agents hold great promise in …
radiation and cytotoxic chemotherapies. Molecularly targeted agents hold great promise in …
[HTML][HTML] Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs
AR Safa, MR Saadatzadeh, AA Cohen-Gadol… - Genes & diseases, 2015 - Elsevier
Cancer stem cells (CSCs) or cancer initiating cells (CICs) maintain self-renewal and
multilineage differentiation properties of various tumors, as well as the cellular heterogeneity …
multilineage differentiation properties of various tumors, as well as the cellular heterogeneity …
Multiregional radiomics features from multiparametric MRI for prediction of MGMT methylation status in glioblastoma multiforme: a multicentre study
Objectives To build a reliable radiomics model from multiregional and multiparametric
magnetic resonance imaging (MRI) for pretreatment prediction of O 6-methylguanine-DNA …
magnetic resonance imaging (MRI) for pretreatment prediction of O 6-methylguanine-DNA …
[HTML][HTML] DNA repair mechanisms and their clinical impact in glioblastoma
H Erasimus, M Gobin, S Niclou, E Van Dyck - Mutation Research/Reviews …, 2016 - Elsevier
Despite surgical resection and genotoxic treatment with ionizing radiation and the DNA
alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in …
alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in …
Deep penetrating and sensitive targeted magnetic particle imaging and photothermal therapy of early‐stage glioblastoma based on a biomimetic nanoplatform
Early diagnosis can effectively improve the survival of glioblastoma multiforme (GBM). A
specific imaging technique that is simultaneously deep penetrating and sensitive to small …
specific imaging technique that is simultaneously deep penetrating and sensitive to small …