Chemically modified and conjugated antimicrobial peptides against superbugs
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms
AH Benfield, ST Henriques - Frontiers in Medical Technology, 2020 - frontiersin.org
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …
Antimicrobial Bacillus: Metabolites and Their Mode of Action
C Tran, IE Cock, X Chen, Y Feng - Antibiotics, 2022 - mdpi.com
The agricultural industry utilizes antibiotic growth promoters to promote livestock growth and
health. However, the World Health Organization has raised concerns over the ongoing …
health. However, the World Health Organization has raised concerns over the ongoing …
Natural antimicrobial lipopeptides secreted by Bacillus spp. and their application in food preservation, a critical review
B Zhang, L Xu, J Ding, M Wang, R Ge, H Zhao… - Trends in Food Science …, 2022 - Elsevier
Background Microbial infection is one of the biggest causes of food spoilage. Thus,
preventing food from microbial-related spoilage has been one of the main concerns for the …
preventing food from microbial-related spoilage has been one of the main concerns for the …
Antibiotic adjuvants: an alternative approach to overcome multi-drug resistant Gram-negative bacteria
Antibiotic resistance in Gram-negative pathogens has emerged and constituted a global
crisis, thereby novel antibiotics and other anti-infective strategies are urgently needed …
crisis, thereby novel antibiotics and other anti-infective strategies are urgently needed …
Antimicrobial peptides with high proteolytic resistance for combating gram-negative bacteria
J Wang, J Song, Z Yang, S He, Y Yang… - Journal of medicinal …, 2019 - ACS Publications
Poor proteolytic resistance is an urgent problem to be solved in the clinical application of
antimicrobial peptides (AMPs), yet common solutions, such as complicated chemical …
antimicrobial peptides (AMPs), yet common solutions, such as complicated chemical …
Nonribosomal antibacterial peptides that target multidrug-resistant bacteria
Y Liu, S Ding, J Shen, K Zhu - Natural product reports, 2019 - pubs.rsc.org
Covering: 2000 to 2018, particularly from 2010 to early 2018 The increase in the incidence
of antibiotic resistant infections is threatening to overwhelm healthcare practices worldwide …
of antibiotic resistant infections is threatening to overwhelm healthcare practices worldwide …
Structure, properties, and biological functions of nonribosomal lipopeptides from pseudomonads
Bacteria of the genus Pseudomonas are ubiquitous in nature. Pseudomonads display a
fascinating metabolic diversity, which correlates with their ability to colonize an extremely …
fascinating metabolic diversity, which correlates with their ability to colonize an extremely …
[HTML][HTML] Emerging peptide antibiotics with therapeutic potential
G Upert, A Luther, D Obrecht, P Ermert - Medicine in drug discovery, 2021 - Elsevier
This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …
on compounds with novel or established mode of action and with demonstrated efficacy in …