Precise regulation of mRNA translation is of fundamental importance for maintaining
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …

Translation termination is an essential cellular process, which is also of therapeutic interest
for diseases that manifest from premature stop codons. In eukaryotes, translation termination …

It is known that mRNAs and the machinery that translates them are not uniformly distributed
throughout the cytoplasm. As a result, the expression of some genes is localized to particular …

Nonsense mutations–the underlying cause of approximately 11% of all genetic diseases–
prematurely terminate protein synthesis by mutating a sense codon to a premature stop or …

Reactive aldehydes are abundant endogenous metabolites that challenge homeostasis by
crosslinking cellular macromolecules. Aldehyde-induced DNA damage requires repair to …

Reactive aldehydes are produced by normal cellular metabolism or after alcohol
consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are …

Nonsense mutations account for> 10% of human genetic disorders, including cystic fibrosis,
Alagille syndrome, and Duchenne muscular dystrophy. A nonsense mutation results in the …

Translation control mechanisms connect the largely static genome to the highly dynamic
proteome. At each step in the translation cycle, multiple layers of regulation enable efficient …

GCN1 is a highly conserved protein present widely across eukaryotes. As an upstream
activator of protein kinase GCN2, GCN1 plays a pivotal role in integrated stress responses …

Discovered more than four decades ago, nonsense-mediated mRNA decay (NMD) plays a
fundamental role in the regulation of gene expression and is a major contributor to …