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The molecular principles of gene regulation by Polycomb repressive complexes
NP Blackledge, RJ Klose - Nature reviews Molecular cell biology, 2021 - nature.com
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Regulation, functions and transmission of bivalent chromatin during mammalian development
TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity
Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …
replication and can be inherited through mitosis. How this may sustain the epigenome and …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
S Jessa, A Mohammadnia, AS Harutyunyan… - Nature …, 2022 - nature.com
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
Molecular mechanisms directing PRC2 recruitment and H3K27 methylation
A Laugesen, JW Højfeldt, K Helin - Molecular cell, 2019 - cell.com
The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …
[HTML][HTML] Histone H2AK119 mono-ubiquitination is essential for polycomb-mediated transcriptional repression
S Tamburri, E Lavarone, D Fernández-Pérez… - Molecular cell, 2020 - cell.com
Polycomb group proteins (PcGs) maintain transcriptional repression to preserve cellular
identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by …
identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by …
Chromatin replication and epigenetic cell memory
Propagation of the chromatin landscape across cell divisions is central to epigenetic cell
memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and …
memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and …
Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation
MAJ Morgan, A Shilatifard - Nature genetics, 2020 - nature.com
Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …
processes including gene expression. Here, we outline historical and current thinking …
Context-specific Polycomb mechanisms in development
JJ Kim, RE Kingston - Nature Reviews Genetics, 2022 - nature.com
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
AS Harutyunyan, B Krug, H Chen… - Nature …, 2019 - nature.com
Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly
gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M …
gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M …