Notes on syphilis vaccine development
The quest for a syphilis vaccine to provide protection from infection or disease began not
long after the isolation of the first Treponema pallidum subspecies pallidum (T. pallidum) …
long after the isolation of the first Treponema pallidum subspecies pallidum (T. pallidum) …
A suite of PCR-LwCas13a assays for detection and genoty** of Treponema pallidum in clinical samples
The performance of commonly used assays for diagnosis of syphilis varies considerably
depending on stage of infection and sample type. In response to the need for improved …
depending on stage of infection and sample type. In response to the need for improved …
Omics detection and treatment of syphilis
X Shi, J Shi, F Zou, Q Cao, X Yan, S Liu, Y Li, X Lan - Clinica Chimica Acta, 2024 - Elsevier
Treponema pallidum is the source of the chronic systemic sexually transmitted illness
syphilis. T. pallidum can evade immunity and spread. A hard chancre, enlarged lymph …
syphilis. T. pallidum can evade immunity and spread. A hard chancre, enlarged lymph …
Clonal isolates of Treponema pallidum subsp. pallidum Nichols provide evidence for the occurrence of microevolution during experimental rabbit infection and in vitro …
The recent development of a system for long-term in vitro culture of the syphilis spirochete,
Treponema pallidum subsp. pallidum, has introduced the possibility of detailed genetic …
Treponema pallidum subsp. pallidum, has introduced the possibility of detailed genetic …
Clinical and genomic diversity of Treponema pallidum subspecies pallidum to inform vaccine research: an international, molecular epidemiology study
Background The increase in syphilis rates worldwide necessitates development of a vaccine
with global efficacy. We aimed to explore Treponema pallidum subspecies pallidum (TPA) …
with global efficacy. We aimed to explore Treponema pallidum subspecies pallidum (TPA) …
Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients' ulcers in Namatanai District of Papua New Guinea: Local human population …
M Medappa, P Pospíšilová, MPM Madruga… - PLoS neglected …, 2024 - journals.plos.org
Yaws is an endemic disease caused by Treponema pallidum subsp. pertenue (TPE) that
primarily affects children in rural regions of the tropics. The endemic character of yaws …
primarily affects children in rural regions of the tropics. The endemic character of yaws …
High frequency of Nichols-like strains and increased levels of macrolide resistance in Treponema pallidum in clinical samples from Buenos Aires, Argentina
N Morando, E Vrbová, A Melgar, RD Rabinovich… - Scientific Reports, 2022 - nature.com
Globally, 94% of Treponema pallidum subsp. pallidum (TPA) clinical strains belong to the
SS14-like group and 6% to the Nichols-like group, with a prevalence of macrolide resistance …
SS14-like group and 6% to the Nichols-like group, with a prevalence of macrolide resistance …
Redefining the treponemal history through pre-Columbian genomes from Brazil
The origins of treponemal diseases have long remained unknown, especially considering
the sudden onset of the first syphilis epidemic in the late 15th century in Europe and its …
the sudden onset of the first syphilis epidemic in the late 15th century in Europe and its …
PathoGD: an integrative genomics approach to primer and guide RNA design for CRISPR-based diagnostics
Critical to the success of CRISPR-based diagnostic assays is the selection of a diagnostic
target highly specific to the organism of interest, a process often requiring iterative cycles of …
target highly specific to the organism of interest, a process often requiring iterative cycles of …
Clinical and genomic diversity of Treponema pallidum subsp. pallidum: A global, multi-center study of early syphilis to inform vaccine research
Background The continuing increase in syphilis rates worldwide necessitates development
of a vaccine with global efficacy. We conducted a multi-center, observational study to …
of a vaccine with global efficacy. We conducted a multi-center, observational study to …