Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …

Macrophages are crucial members of the innate immune response and important regulators.
The differentiation and activation of macrophages require the timely regulation of gene …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many
aspects of the immune response. Intracellular levels generally respond to variations in …

In addition to their early-recognized functions in host defense and the clearance of apoptotic
cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If …

Simple Summary Epigenetic mechanisms including methylation play an essential role in
regulating gene expression not only in cancer cells but also in immune cells. Although role …

Tumor-associated macrophages (TAM) plasticity and diversity are both essential hallmarks
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …

Over the last decade, our understanding of the physiological role of senescent cells has
drastically evolved, from merely indicators of cellular stress and ageing to having a central …

Rheumatoid arthritis (RA) is characterized by immune dysfunctions and chronic
inflammation that mainly affects diarthrodial joints. Genetics has long been surveyed in …

DNA methylation is a dynamic epigenetic modification with a prominent role in determining
mammalian cell development, lineage identity, and transcriptional regulation. Primarily …