Nicotinic acetylcholine receptors in neuropathic and inflammatory pain
AJ Hone, JM McIntosh - FEBS letters, 2018 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic
targets for the treatment of pain and inflammation, but despite more than 30 years of …
targets for the treatment of pain and inflammation, but despite more than 30 years of …
Block of voltage-gated calcium channels by peptide toxins
Venoms from various predatory species, such as fish hunting molluscs scorpions, snakes
and arachnids contain a large spectrum of toxins that include blockers of voltage-gated …
and arachnids contain a large spectrum of toxins that include blockers of voltage-gated …
Subcutaneous ω-conotoxins alleviate mechanical pain in rodent models of acute peripheral neuropathy
The peripheral effects of ω-conotoxins, selective blockers of N-type voltage-gated calcium
channels (CaV2. 2), have not been characterised across different clinically relevant pain …
channels (CaV2. 2), have not been characterised across different clinically relevant pain …
[ZITATION][C] The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury
Changes in ion channel function and expression are characteristic of neuropathic pain.
Voltage-gated calcium channels (VGCCs) are integral for neurotransmission and membrane …
Voltage-gated calcium channels (VGCCs) are integral for neurotransmission and membrane …
[PDF][PDF] Structure, function and regulation of CaV 2.2 N-type calcium channels
B Jurkovicova-Tarabova, L Lacinova - Gen Physiol Biophys, 2019 - researchgate.net
N-type or CaV2. 2 high-voltage activated calcium channels are distinguished by exclusively
neuronal tissue distribution, sensitivity to ω-conotoxins, prominent inhibition by G-proteins …
neuronal tissue distribution, sensitivity to ω-conotoxins, prominent inhibition by G-proteins …
Marine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential
Neuropathic pain, a challenging condition often associated with diabetes, trauma, or
chemotherapy, impairs patients' quality of life. Current treatments often provide inconsistent …
chemotherapy, impairs patients' quality of life. Current treatments often provide inconsistent …
Potential uses of isolated toxin peptides in neuropathic pain relief: a literature review
MK Hamad, K He, HF Abdulrazeq, AM Mustafa… - World neurosurgery, 2018 - Elsevier
Highlights•Drugs derived from naturally occurring toxins may aid in treating neuropathic
pain.•Researching the impact of toxins on animals may lead to consideration for clinical …
pain.•Researching the impact of toxins on animals may lead to consideration for clinical …
Voltage-gated calcium channels in the afferent pain pathway
L Ferron, GW Zamponi - Voltage-Gated Calcium Channels, 2022 - Springer
Voltage-gated calcium channels are important mediators of signal transduction in the
primary afferent pain pathway. In rodents, T-type calcium channels regulate the excitability of …
primary afferent pain pathway. In rodents, T-type calcium channels regulate the excitability of …
Effects of arginine 10 to lysine substitution on ω‐conotoxin CVIE and CVIF block of Cav2.2 channels
Background and Purpose ω‐Conotoxins CVIE and CVIF (CVIE & F) selectively inhibit Cav
2.2 channels and are lead molecules in the development of novel analgesics. At …
2.2 channels and are lead molecules in the development of novel analgesics. At …