Guidelines for the measurement of vascular function and structure in isolated arteries and veins
The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …
into the structural, functional, and biomechanical features of the normal and diseased …
[HTML][HTML] The emerging role of in vitro electrophysiological methods in CNS safety pharmacology
MV Accardi, MK Pugsley, R Forster, E Troncy… - … of pharmacological and …, 2016 - Elsevier
Adverse CNS effects account for a sizeable proportion of all drug attrition cases. These
adverse CNS effects are mediated predominately by off-target drug activity on neuronal ion …
adverse CNS effects are mediated predominately by off-target drug activity on neuronal ion …
Astrocytic K+ clearance during disease progression in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder in which patients lose
motor functions due to progressive loss of motor neurons in the cortex, brainstem, and spinal …
motor functions due to progressive loss of motor neurons in the cortex, brainstem, and spinal …
Applicability of hiPSC-Derived Neuronal Cocultures and Rodent Primary Cortical Cultures for In Vitro Seizure Liability Assessment
AM Tukker, FMJ Wijnolts, A de Groot… - Toxicological …, 2020 - academic.oup.com
Seizures are life-threatening adverse drug reactions which are investigated late in drug
development using rodent models. Consequently, if seizures are detected, a lot of time …
development using rodent models. Consequently, if seizures are detected, a lot of time …
A living ex vivo platform for functional, personalized brain cancer diagnosis
B Mann, X Zhang, N Bell, A Adefolaju, M Thang… - Cell Reports …, 2023 - cell.com
Functional precision medicine platforms are emerging as promising strategies to improve
pre-clinical drug testing and guide clinical decisions. We have developed an organotypic …
pre-clinical drug testing and guide clinical decisions. We have developed an organotypic …
Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment
AM Tukker, RGDM Van Kleef, FMJ Wijnolts… - ALTEX-Alternatives to …, 2020 - altex.org
A sizeable proportion of drug attrition is due to drug-induced seizures. Currently available
animal models frequently fail to predict human seizure liability. Therefore, there is a need for …
animal models frequently fail to predict human seizure liability. Therefore, there is a need for …
Fast Metabolic Glycan Labeling for Click-Labeling and Imaging of Sialoglycans in Living Acute Brain Slices from Mice and Human Patients
Living acute brain slices provide a practical platform for imaging sialylation in human brain
pathology. However, the limited lifespan of acute brain slices has impeded the use of …
pathology. However, the limited lifespan of acute brain slices has impeded the use of …
Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum
Background Low-grade, chronic inflammation in the central nervous system characterized
by glial reactivity is one of the major hallmarks for aging-related neurodegenerative …
by glial reactivity is one of the major hallmarks for aging-related neurodegenerative …
Neuronal loss of the glutamate transporter GLT-1 promotes excitotoxic injury in the hippocampus
GLT-1, the major glutamate transporter in the mammalian central nervous system, is
expressed in presynaptic terminals that use glutamate as a neurotransmitter, in addition to …
expressed in presynaptic terminals that use glutamate as a neurotransmitter, in addition to …
Astrocytic modulation of cortical oscillations
Brain waves are rhythmic voltage oscillations emerging from the synchronization of
individual neurons into a neuronal network. These oscillations range from slow to fast …
individual neurons into a neuronal network. These oscillations range from slow to fast …