The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …

Brain disorders, encompassing a wide spectrum of neurological and psychiatric conditions,
present a formidable challenge in modern medicine. Despite decades of research, the …

Functional precision medicine platforms are emerging as promising strategies to improve
pre-clinical drug testing and guide clinical decisions. We have developed an organotypic …

Seizures are life-threatening adverse drug reactions which are investigated late in drug
development using rodent models. Consequently, if seizures are detected, a lot of time …

Adverse CNS effects account for a sizeable proportion of all drug attrition cases. These
adverse CNS effects are mediated predominately by off-target drug activity on neuronal ion …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder in which patients lose
motor functions due to progressive loss of motor neurons in the cortex, brainstem, and spinal …

Living acute brain slices provide a practical platform for imaging sialylation in human brain
pathology. However, the limited lifespan of acute brain slices has impeded the use of …

GLT-1, the major glutamate transporter in the mammalian central nervous system, is
expressed in presynaptic terminals that use glutamate as a neurotransmitter, in addition to …

Background Low-grade, chronic inflammation in the central nervous system characterized
by glial reactivity is one of the major hallmarks for aging-related neurodegenerative …

A sizeable proportion of drug attrition is due to drug-induced seizures. Currently available
animal models frequently fail to predict human seizure liability. Therefore, there is a need for …