The “neuro-glial-vascular” unit: the role of glia in neurovascular unit formation and dysfunction
The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …
The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target
DS Boyer, U Schmidt-Erfurth… - Retina, 2017 - journals.lww.com
Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
[HTML][HTML] Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial
Purpose Geographic atrophy (GA), a late stage of age-related macular degeneration (AMD),
is a major cause of blindness. Even while central visual acuity remains relatively well …
is a major cause of blindness. Even while central visual acuity remains relatively well …
Oxidative stress and antioxidants in age-related macular degeneration
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …
Molecular pathology of age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex …
world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex …
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD
Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease
with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a …
with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a …
Animal models of age related macular degeneration
ME Pennesi, M Neuringer, RJ Courtney - Molecular aspects of medicine, 2012 - Elsevier
Age related macular degeneration (AMD) is the leading cause of vision loss of those over
the age of 65 in the industrialized world. The prevalence and need to develop effective …
the age of 65 in the industrialized world. The prevalence and need to develop effective …
Central role of oxidative stress in age‐related macular degeneration: evidence from a review of the molecular mechanisms and animal models
Age‐related macular degeneration (AMD) is a common cause of visual impairment in the
elderly. There are very limited therapeutic options for AMD with the predominant therapies …
elderly. There are very limited therapeutic options for AMD with the predominant therapies …
Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …
[HTML][HTML] A new perspective on lipid research in age-related macular degeneration
EM van Leeuwen, E Emri, BMJ Merle, JM Colijn… - Progress in retinal and …, 2018 - Elsevier
There is an urgency to find new treatment strategies that could prevent or delay the onset or
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …