Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Mitochondria take up Ca2+ through the mitochondrial calcium uniporter complex to regulate
energy production, cytosolic Ca2+ signalling and cell death,. In mammals, the uniporter …

Traumatic brain injury (TBI) is a major health concern worldwide and is classified based on
severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic …

The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II
apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy …

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Mitochondrial oxidative stress has been reported as the result of respiratory complex
anomalies, genetic defects, or insufficient oxygen or glucose supply. Although Ca2+ has no …

Traumatic brain injury (TBI) is a major health and socioeconomic problem throughout the
world. It is a complicated pathological process that consists of primary insults and a …

Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …