Fluctuating selection and the determinants of genetic variation

OL Johnson, R Tobler, JM Schmidt, CD Huber - Trends in Genetics, 2023 - cell.com
Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands
of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating …

The roles of sexual selection and sexual conflict in sha** patterns of genome and transcriptome variation

NM Tosto, ER Beasley, BBM Wong, JE Mank… - Nature Ecology & …, 2023 - nature.com
Sexual dimorphism is one of the most prevalent, and often the most extreme, examples of
phenotypic variation within species, and arises primarily from genomic variation that is …

Balancing selection via life-history trade-offs maintains an inversion polymorphism in a seaweed fly

C Mérot, V Llaurens, E Normandeau… - Nature …, 2020 - nature.com
How natural diversity is maintained is an evolutionary puzzle. Genetic variation can be
eroded by drift and directional selection but some polymorphisms persist for long time …

Antagonistic pleiotropy in human disease

SG Byars, K Voskarides - Journal of Molecular Evolution, 2020 - Springer
Between the 1930s and 1950s, scientists developed key principles of population genetics to
try and explain the aging process. Almost a century later, these aging theories, including …

Beyond large-effect loci: large-scale GWAS reveals a mixed large-effect and polygenic architecture for age at maturity of Atlantic salmon

M Sinclair-Waters, J Ødegård, SA Korsvoll… - Genetics Selection …, 2020 - Springer
Background Understanding genetic architecture is essential for determining how traits will
change in response to evolutionary processes such as selection, genetic drift and/or gene …

The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics

F Ruzicka, L Dutoit, P Czuppon, CY Jordan… - Evolution …, 2020 - academic.oup.com
Sexually antagonistic (SA) genetic variation—in which alleles favored in one sex are
disfavored in the other—is predicted to be common and has been documented in several …

[PDF][PDF] Sex-specific dominance of gene expression in seed beetles

P Kaufmann, JL Rönn, E Immonen… - Molecular biology and …, 2024 - academic.oup.com
When different alleles are favored in different environments, dominance reversal where
alternate alleles are dominant in the environment in which they are favored can generate net …

Pleiotropic fitness effects across sexes and ages in the Drosophila genome and transcriptome

HWS Wong, L Holman - Evolution, 2023 - academic.oup.com
Selection varies between categories of individuals, with far-reaching ramifications: Sex-
specific selection can impede or accelerate adaptation, and differences in selection between …

Limits to genomic divergence under sexually antagonistic selection

KR Kasimatis, PL Ralph… - G3: Genes, Genomes …, 2019 - academic.oup.com
Since the autosomal genome is shared between the sexes, sex-specific fitness optima
present an evolutionary challenge. While sexually antagonistic selection might favor …

Sexually antagonistic selection maintains genetic variance when sexual dimorphism evolves

P Kaufmann, JM Howie… - Proceedings of the …, 2023 - royalsocietypublishing.org
Genetic variance (VG) in fitness related traits is often unexpectedly high, evoking the
question how VG can be maintained in the face of selection. Sexually antagonistic (SA) …