Molecularly generated light and its biomedical applications

C Ran, K Pu - Angewandte Chemie International Edition, 2024 - Wiley Online Library
Molecularly generated light, referred to here as “molecular light”, mainly includes
bioluminescence, chemiluminescence, and Cerenkov luminescence. Molecular light …

Single‐Particle and Single‐Molecule Characterization of Immobilized Enzymes: A Multiscale Path toward Optimizing Heterogeneous Biocatalysts

E Diamanti, F López‐Gallego - … Chemie International Edition, 2024 - Wiley Online Library
Heterogeneous biocatalysis is highly relevant in biotechnology as it offers several benefits
and practical uses. To leverage the full potential of heterogeneous biocatalysts, the …

Precise immunofluorescence canceling for highly multiplexed imaging to capture specific cell states

K Tomimatsu, T Fujii, R Bise, K Hosoda… - Nature …, 2024 - nature.com
Cell states are regulated by the response of signaling pathways to receptor ligand-binding
and intercellular interactions. High-resolution imaging has been attempted to explore the …

Suppression of the JAK/STAT pathway inhibits neuroinflammation in the line 61-PFF mouse model of Parkinson's disease

H Hong, Y Wang, M Menard, JA Buckley… - Journal of …, 2024 - Springer
Parkinson's disease (PD) is characterized by neuroinflammation, progressive loss of
dopaminergic neurons, and accumulation of α-synuclein (α-Syn) into insoluble aggregates …

Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and protein levels

M Wong, Y Wei, YC Ho - Current Opinion in HIV and AIDS, 2023 - journals.lww.com
Current Opinion in HIV and AIDS Log in or Register Subscribe to journalSubscribe Get new
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Integrating single-cell RNA-seq datasets with substantial batch effects

K Hrovatin, AA Moinfar, L Zappia, AT Lapuerta… - …, 2024 - pmc.ncbi.nlm.nih.gov
Integration of single-cell RNA-sequencing (scRNA-seq) datasets has become a standard
part of the analysis, with conditional variational autoencoders (cVAE) being among the most …

Identifying Reproducible Transcription Regulator Coexpression Patterns with Single Cell Transcriptomics

A Morin, CP Chu, P Pavlidis - bioRxiv, 2025 - pmc.ncbi.nlm.nih.gov
Author Summary A common way to analyze gene expression (transcriptomics) data is to
correlate gene transcript levels across samples for every pair of genes (coexpression) …

Single-Cell Atlas of AML Reveals Age-Related Gene Regulatory Networks in t (8; 21) AML

J Whittle, S Meyer, G Lacaud, SM Baker, M Iqbal - bioRxiv, 2024 - biorxiv.org
Background Acute myeloid leukemia (AML) is characterized by cellular and genetic
heterogeneity, which correlates with clinical course. Although single-cell RNA sequencing …

Seeing or believing in hyperplexed spatial proteomics via antibodies: New and old biases for an image-based technology

MM Bolognesi, L Dall'Olio, A Maerten, S Borghesi… - Biological …, 2024 - cambridge.org
Hyperplexed in-situ targeted proteomics via antibody immunodetection (ie,> 15 markers) is
changing how we classify cells and tissues. Differently from other high-dimensional single …