The centrosome cycle: centriole biogenesis, duplication and inherent asymmetries
Centrosomes are microtubule-organizing centres of animal cells. They influence the
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …
Causes and consequences of centrosome abnormalities in cancer
Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …
recent years, we are still far from understanding how centrosome amplification affects …
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
Multiple centrosomes in tumor cells create the potential for multipolar divisions that can lead
to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because …
to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because …
[HTML][HTML] Evolution: Tracing the origins of centrioles, cilia, and flagella
Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate
the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral …
the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral …
Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization
As the main microtubule-organizing centre in animal cells, the centrosome has a
fundamental role in cell function. Surrounding the centrioles, the pericentriolar material …
fundamental role in cell function. Surrounding the centrioles, the pericentriolar material …
[HTML][HTML] Structural basis of the 9-fold symmetry of centrioles
The centriole, and the related basal body, is an ancient organelle characterized by a
universal 9-fold radial symmetry and is critical for generating cilia, flagella, and centrosomes …
universal 9-fold radial symmetry and is critical for generating cilia, flagella, and centrosomes …
Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole
M Ohta, T Ashikawa, Y Nozaki, H Kozuka-Hata… - Nature …, 2014 - nature.com
Formation of one procentriole next to each pre-existing centriole is essential for centrosome
duplication, robust bipolar spindle assembly and maintenance of genome integrity …
duplication, robust bipolar spindle assembly and maintenance of genome integrity …
Towards a molecular architecture of centriole assembly
P Gönczy - Nature reviews Molecular cell biology, 2012 - nature.com
The centriole is an evolutionarily conserved macromolecular structure that is crucial for the
formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first …
formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first …
Structures of SAS-6 suggest its organization in centrioles
Centrioles are cylindrical, ninefold symmetrical structures with peripheral triplet microtubules
strictly required to template cilia and flagella. The highly conserved protein SAS-6 …
strictly required to template cilia and flagella. The highly conserved protein SAS-6 …
The centrosome and its duplication cycle
The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …
Long recognized as a key organelle of the spindle pole, its core component, the centriole …