Articular cartilage repair and regeneration continue to be largely intractable because of the
poor regenerative properties of this tissue. The field of articular cartilage tissue engineering …

The lack of in vitro tissue and organ models capable of mimicking human physiology
severely hinders the development and clinical translation of therapies and drugs with higher …

BACKGROUND: The developmental history of the chondrocyte results in a cell whose
biosynthetic activities are optimized to maintain the concentration and organization of a …

Abnormal mechanical loading often leads to the progressive degradation of cartilage and
causes osteoarthritis (OA). Although multiple mechanoresponsive strategies based on …

The effects of exercise on articular hyaline articular cartilage have traditionally been
examined in animal models, but until recently little information has been available on human …

Cell selection, scaffold design and biological stimulation remain the challenges of function
tissue engineering. Successful regeneration or replacement of damaged or diseased …

Damage to and degeneration of articular cartilage is a major health issue in industrialized
nations. Articular cartilage has a particularly limited capacity for auto regeneration. At …

Mechanical loading to the knee joint results in a differential response based on the local
capacity of the tissues (ligament, tendon, meniscus, cartilage, and bone) and how those …

The use of tissue-engineered articular cartilage (TEAC) constructs has the potential to
become a powerful treatment option for cartilage lesions resulting from trauma or early …

The ex vivo engineering of autologous cartilage tissues has the potential to revolutionize the
clinical management of joint disorders. Yet, high manufacturing costs and variable outcomes …