Alzheimer's disease: an updated overview of its genetics

J Andrade-Guerrero, A Santiago-Balmaseda… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

[PDF][PDF] Amyloid-β and phosphorylated tau are the key biomarkers and predictors of Alzheimer's disease

H Reddy, S Kshirsagar, MA Islam, J Baig… - Aging and …, 2025 - researchgate.net
Alzheimer's disease (AD) is a age-related neurodegenerative disease and is a major public
health concern both in Texas, US and Worldwide. This neurodegenerative disease is mainly …

[HTML][HTML] The Kynurenine Pathway, Aryl Hydrocarbon Receptor, and Alzheimer's Disease

EM Cortés Malagón, A López Ornelas, I Olvera Gómez… - Brain Sciences, 2024 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia, mainly affecting elderly
individuals. AD is characterized by β-amyloid plaques, abnormal tau tangles, neuronal loss …

Exercised-enriched blood plasma rescues hippocampal impairments and cognitive deficits in an Alzheimer's disease model

T Huang, X Gong, Z Liang, R Yang, L Wu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and moderate
exercise holds promise in ameliorating the ongoing neurodegeneration and cognitive …

New insights toward molecular and nanotechnological approaches to antidiabetic agents for Alzheimer's disease

SP Pradhan, PK Sahu, A Behera - Molecular and Cellular Biochemistry, 2023 - Springer
Alzheimer's disease (AD) is a chronic neurodegenerative disorder affecting a major class of
silver citizens. The disorder shares a mutual relationship on account of its cellular and …

Proteomic tools to study phosphorylation of intrinsically disordered proteins

B Spolaore, L Secco, G Rocca… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Intrinsically disordered proteins (IDPs) represent a family of
proteins that lack secondary or tertiary structure. IDPs are hubs in interaction networks …

Targeting Tau in Alzheimer's and Beyond: Insights into Pathology and Therapeutic Strategies

S Singh, S Khan, M Shahid, M Sardar, MI Hassan… - Ageing Research …, 2024 - Elsevier
Tauopathies encompass a group of approximately 20 neurodegenerative diseases
characterized by the accumulation of the microtubule-associated protein tau in brain …

Drug Target to Alleviate Mitochondrial Dysfunctions in Alzheimer's Disease: Recent Advances and Therapeutic Implications

MA Rahman, MDH Rahman, H Rhim… - Current …, 2024 - benthamdirect.com
Alzheimer's disease (AD) is a severe progressive neurodegenerative condition associated
with neuronal damage and reduced cognitive function that primarily affects the aged …

[HTML][HTML] 27-Hydroxycholesterol-induced dysregulation of cholesterol metabolism impairs learning and memory ability in ApoE ε4 transgenic mice

Y Wang, L Hao, T Wang, W Liu, L Wang, M Ju… - International Journal of …, 2022 - mdpi.com
Dysregulated brain cholesterol metabolism is one of the characteristics of Alzheimer's
disease (AD). 27-Hydroxycholesterol (27-OHC) is a cholesterol metabolite that plays an …

The role of neurons in human health and disease

YM Akay - International Journal of Molecular Sciences, 2023 - mdpi.com
Neurons are the functional units of the nervous system. They are responsible for carrying
stimuli throughout the human body and help coordinate all of the necessary functions of life …