Aging is characterized by changes in the structure and quality of sleep. When the alterations
in sleep become substantial, they can generate or accelerate cognitive decline, even in the …

As life expectancy continues to increase worldwide, age-related dysfunction will largely
impact our societies in the future. Aging is well established to promote the deterioration of …

Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early
biomarker in human cognitive impairment. However, the relationship between BBB …

Vitamin E has been proposed as a potential clinical intervention for Alzheimer's disease
(AD) given the plausibility of its various biological functions in influencing the …

Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of
Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative …

Tau deposits in astrocytes are frequently found in Alzheimer's disease (AD) and other
tauopathies. Since astrocytes do not express tau, the inclusions have been suggested to be …

Purpose To explore regional variation of the macular microvasculature in patients with mild
cognitive impairment (MCI) and Alzheimer's disease (AD), also to detect the association …

The brain of patients with Alzheimer disease (AD) showed the evidence of reduced
expression of insulin and neuronal insulin receptors, as compared with those of age …

The vascular endothelium in the brain is an essential part of the blood-brain-barrier (BBB)
because of its very tight structure to secure a functional and molecular separation of the …

Ethnopharmacological relevance This review explores the link between Type 2 Diabetes
Mellitus (T2DM) and diabetes-induced Alzheimer's disease (AD). It emphasizes the shared …