Advances in the treatment of mucoepidermoid carcinoma

S Sama, T Komiya, AK Guddati - World Journal of Oncology, 2021 - pmc.ncbi.nlm.nih.gov
Mucoepidermoid carcinoma (MEC) represents 10-15% of salivary neoplasms. Due to their
low incidence, it is challenging to conduct clinical trials and develop treatment guidelines …

A molecular guide to systemic therapy in salivary gland carcinoma

AN Weaver, S Lakritz, D Mandair, MB Ulanja… - Head & …, 2023 - Wiley Online Library
Salivary gland carcinomas (SGC) are a rare and variable group of head and neck cancers
with historically poor response to cytotoxic chemotherapy and immunotherapy in the …

Aberrantly activated AREG–EGFR signaling is required for the growth and survival of CRTC1–MAML2 fusion-positive mucoepidermoid carcinoma cells

Z Chen, J Chen, Y Gu, C Hu, JL Li, S Lin, H Shen… - Oncogene, 2014 - nature.com
Salivary gland tumors (SGT) are a group of highly heterogeneous head and neck
malignancies with widely varied clinical outcomes and no standard effective treatments. The …

Advances and challenges in precision medicine in salivary gland cancer

G Lassche, W van Boxtel, MJL Ligtenberg… - Cancer treatment …, 2019 - Elsevier
Salivary gland cancer (SGC) is a rare malignancy consisting of 22 subtypes with different
genetic, histological and clinical characteristics. This rarity and heterogeneity makes …

Mucoepidermoid carcinoma of the salivary gland: demographics and comparative analysis in US children and adults with future perspective of management

A Ullah, J Khan, A Waheed, NR Karki, M Goodbee… - Cancers, 2022 - mdpi.com
Simple Summary Salivary gland tumors are rare among both pediatric and adult
populations. Mucoepidermoid carcinoma (MEC) is a common type of malignant salivary …

Molecular targets in salivary gland cancers: a comprehensive genomic analysis of 118 mucoepidermoid carcinoma tumors

M Bou Zerdan, PA Kumar, D Zaccarini, J Ross… - Biomedicines, 2023 - mdpi.com
Introduction: Salivary gland carcinomas (SGC) are histologically diverse cancers and next-
generation sequencing (NGS) to identify key molecular targets is an important aspect in the …

Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells

DM Guimarães, LO Almeida, MD Martins… - …, 2016 - pmc.ncbi.nlm.nih.gov
Mucoepidermoid carcinoma (MEC) is the most common malignancy of salivary glands. The
response of MEC to chemotherapy is unpredictable, and recent advances in cancer biology …

Activation of the EGFR/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands

B Lujan, S Hakim, S Moyano, A Nadal… - British journal of …, 2010 - nature.com
Background: Mucoepidermoid carcinoma (MEC) shows differences in biological behaviour
depending mainly on its histological grade. High-grade tumours usually have an aggressive …

Clinicopathological significance of EGFR pathway gene mutations and CRTC1/3–MAML2 fusions in salivary gland mucoepidermoid carcinoma

M Morita, T Murase, Y Okumura, K Ueda… - …, 2020 - Wiley Online Library
Aims Mucoepidermoid carcinoma (MEC) is one of the most common salivary gland
carcinomas. Epidermal growth factor receptor (EGFR) signalling pathway gene mutations …

[HTML][HTML] Salivary Gland Cancers in the Era of Molecular Analysis: The Role of Tissue and Liquid Biomarkers

E Broseghini, F Carosi, M Berti, S Compagno… - Cancers, 2025 - mdpi.com
Abstract Background: Salivary gland cancers (SGCs) are a rare and heterogeneous group of
malignancies, accounting for approximately 5% of head and neck cancers. Despite their …