Immune evasion contributes to cancer growth and progression. Cancer cells have the ability
to activate different immune checkpoint pathways that harbor immunosuppressive functions …

Cancer is a borderless global health challenge that continues to threaten human health.
Studies have found that oxidative stress (OS) is often associated with the etiology of many …

Lung cancer is currently the second most common type of cancer with the second incidence
rate and the first mortality rate worldwide. Non‑small cell lung cancer (NSCLC) accounts for …

Cancer is still a leading cause of deaths worldwide, especially due to those cases
diagnosed at late stages with metastases that are still considered untreatable and are …

Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in
disease management, providing a stark contrast to traditional therapeutic approaches like …

Posttranslational modifications (PTMs), such as phosphorylation, methylation, ubiquitination,
and acetylation, are important in governing protein expression levels. Proteolysis targeting …

Lung cancer brain metastasis (LCBM) poses a significant clinical challenge due to acquired
resistance to tyrosine kinase inhibitor (TKI) treatment. To elucidate its underlying …

There is a lack of effective treatments to overcome resistance to EGFR-TKIs in EGFR mutant
tumors. A deeper understanding of resistance mechanisms can provide insights into …

Sulfonamides have gained prominence as versatile agents in cancer therapy, effectively
targeting a spectrum of cancer-associated enzymes. This review provides an extensive …

Lung cancer poses a significant challenge regarding molecular heterogeneity, as it
encompasses a wide range of molecular alterations and cancer-related pathways. Recent …