Myeloperoxidase (MPO) belongs to the family of heme-containing peroxidases, produced
mostly from polymorphonuclear neutrophils. The active enzyme (150 kDa) is the product of …

Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to
respond to inflammatory or infectious etiologies and are crucial participants in the proper …

Stroke is a threatening cerebrovascular disease caused by thrombus with high morbidity
and mortality rates. Neutrophils are the first to be recruited in the brain after stroke, which …

Acute ischemic stroke is a serious life‐threatening disease that affects almost 600 million
people each year throughout the world with a mortality of more than 10%, while two‐thirds of …

Atherothrombosis is a frequent cause of cardiovascular mortality. It is mostly triggered by
plaque rupture and exposure of the thrombogenic subendothelial matrix, which initiates …

Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones
and neutrophil proteases from neutrophils, was first demonstrated as a host defence against …

A state-of-the-art lecture titled “novel mechanisms of thrombo-inflammation during infection”
was presented at the ISTH Congress in 2022. Platelet, neutrophil, and endothelial cell …

Acute ischemic stroke represents a critical, life-threatening condition affecting the central
nervous system. Intravenous thrombolysis with tissue plasminogen activator (tPA) remains a …

Intracellular myeloperoxidase (MPO) plays a specific role in the innate immune response;
however, upon release into the extracellular space in the setting of inflammation, drives …

Platelets play a crucial role in the pathogenesis of stroke and antiplatelet agents exist for its
treatment and prevention. Through the use of LC-MS based protein expression profiling …