The need for improved prediction of clinical response is driving the development of cancer
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …

Modern histologic imaging platforms coupled with machine learning methods have provided
new opportunities to map the spatial distribution of immune cells in the tumor …

Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By develo** a …

Tumors initiate by mutations in cancer cells, and progress through interactions of the cancer
cells with non-malignant cells of the tumor microenvironment. Major players in the tumor …

Recent studies have shown that the tumor extracellular matrix (ECM) associates with
immunosuppression, and that targeting the ECM can improve immune infiltration and …

Biological tissues are not uniquely composed of cells. A substantial part of their volume is
extracellular space, which is primarily filled by an intricate network of macromolecules …

In recent years, the application of advanced analytics, especially artificial intelligence (AI), to
digital H&E images, and other histological image types, has begun to radically change how …

Extracellular matrix (ECM) is a dynamic network of proteins, proteoglycans and
glycosaminoglycans, providing structure to the tissue and biochemical and biomechanical …

Recent research has highlighted the importance of key tumor microenvironment features,
notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and …

Increased immune cell infiltration into tumors is associated with improved patient survival
and predicts response to immune therapies. Thus, identification of factors that determine the …