The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

Characterizing the transcriptome of individual cells is fundamental to understanding
complex biological systems. We describe a droplet-based system that enables 3′ mRNA …

Abstract Interleukin-8 (CXCL8) was originally described as a chemokine whose main
function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on …

Interleukin-8 (IL-8, CXCL8) is a pro-inflammatory chemokine produced by various cell types
to recruit leukocytes to sites of infection or tissue injury. Acquisition of IL-8 and/or its …

Myeloid neoplasms, including acute myeloid leukemia (AML), myeloproliferative neoplasms
(MPNs), and myelodysplastic syndromes (MDS), feature clonal dominance and remodeling …

Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …

The BCL-2 family protein BAX is a central mediator of apoptosis. Overexpression of anti-
apoptotic BCL-2 proteins contributes to tumor development and resistance to therapy by …

Hematopoietic stem and progenitor cells (HSPCs) arise during embryonic development and
are essential for sustaining the blood and immune systems throughout life. Tight regulation …

The distinct clinical features of myelofibrosis (MF) have been attributed in part to
dysregulated inflammatory cytokine production. Circulating cytokine levels are elevated in …