Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …

To discover new drugs to combat COVID-19, an understanding of the molecular basis of
SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of …

The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …

Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

With the advent of next generation sequencing methods and progress in transcriptome
analysis, it became obvious that the human genome contains much more than just protein …

The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene
regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that …

Coronaviruses infect many species of animals including humans, causing acute and chronic
diseases. This review focuses primarily on the pathogenesis of murine coronavirus mouse …

An inducible program of inflammatory gene expression is central to antimicrobial defenses.
This response is controlled by a collaboration involving signal-dependent activation of …